Measurement of Apparent Diffusion Coefficient (ADC) Values of Ependymoma and Medulloblastoma Tumors: a Patient-based Study

H Taheri, M B Tavakoli


Background: aimed to compare the apparent diffusion coefficient (ADC) of two different cerebellar pediatric tumors, including ependymoma and medulloblastoma which have shown similar clinical images in conventional magnetic resonance imaging (MRI) methods.

Material and Methods: Thirty six pediatric patients who were suspected to have the mentioned tumors according to their CT image findings were included in this study. The patients were subjected to conventional MRI protocols followed by diffusion weighted imaging (DWI) and ADC values of the tumors were calculated automatically using MRI scanner software.

Results: The mean (± SD) ADC value for ependymoma (1.2± 0.06 ×10-3 mm2/s) was significantly higher than medulloblastoma (0.87 ± 0.02 ×10-3 mm2/s) (p = 0.041). Moreover, the maximum ADC value of ependymoma was considerably different in comparison with medulloblastoma (1.4 ×10-3 mm2/s and 0.96×10-3 mm2/s, respectively; p = 0.035) Furthermore, the minimum ADC value of ependymoma was higher compared to medulloblastoma (1.0 ×10-3 mm2/s and 0.61×10-3 mm2/s, respectively), but it was not significant (p = 0.067).

Conclusion: Evaluation of ADC values for ependymoma and medulloblastoma is a reliable method to differentiate these two malignancies. This is due to different ADC values reflected during the evaluation.


ADC, DWI, MRI, Pediatric Tumors

Full Text:



eISSN: 2251-7200        JBPE NLM ID: 101589641

Creative Commons License                                                              

                                                                        Chairman and Editor in Chief

                                                                              Dr. Alireza Mehdizadeh

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.

Indexing:  PubMed Central, Scopus, EMBASE, EBSCO, DOAJIndex CopernicusISCSID, Open J-Gate, Geneva Free Medical Journals, EMRmedexBarakatkns, Magiran,  Electronic Journals Library